Influence of infection with non-filarial helminths on the specificity of serological assays for antifilarial immunoglobulin G4.
Identifieur interne : 012C83 ( Main/Exploration ); précédent : 012C82; suivant : 012C84Influence of infection with non-filarial helminths on the specificity of serological assays for antifilarial immunoglobulin G4.
Auteurs : A E Muck [États-Unis] ; M L Pires ; P J LammieSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ]
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (sang), Brésil (épidémiologie), Enfant, Filariose lymphatique (diagnostic), Filariose lymphatique (immunologie), Filariose lymphatique (épidémiologie), Humains, Immunoglobuline G (sang), Sensibilité et spécificité, Strongyloides (immunologie), Strongyloïdose (diagnostic), Strongyloïdose (immunologie), Strongyloïdose (épidémiologie), Sujet âgé, Test ELISA (), Tests sérologiques (), Tests sérologiques (normes), Wuchereria bancrofti (immunologie).
- MESH :
- diagnostic : Filariose lymphatique, Strongyloïdose.
- immunologie : Filariose lymphatique, Strongyloides, Strongyloïdose, Wuchereria bancrofti.
- normes : Tests sérologiques.
- sang : Anticorps antihelminthe, Antigènes d'helminthe, Immunoglobuline G.
- épidémiologie : Brésil, Filariose lymphatique, Strongyloïdose.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Humains, Sensibilité et spécificité, Sujet âgé, Test ELISA, Tests sérologiques.
- Wicri :
- geographic : Brésil.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Animals, Antibodies, Helminth (blood), Antigens, Helminth (blood), Brazil (epidemiology), Child, Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Enzyme-Linked Immunosorbent Assay (methods), Humans, Immunoglobulin G (blood), Middle Aged, Sensitivity and Specificity, Serologic Tests (methods), Serologic Tests (standards), Strongyloides (immunology), Strongyloidiasis (diagnosis), Strongyloidiasis (epidemiology), Strongyloidiasis (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , blood : Antibodies, Helminth, Antigens, Helminth, Immunoglobulin G.
- geographic , epidemiology : Brazil.
- diagnosis : Elephantiasis, Filarial, Strongyloidiasis.
- epidemiology : Elephantiasis, Filarial, Strongyloidiasis.
- immunology : Elephantiasis, Filarial, Strongyloides, Strongyloidiasis, Wuchereria bancrofti.
- methods : Enzyme-Linked Immunosorbent Assay, Serologic Tests.
- standards : Serologic Tests.
- Adolescent, Adult, Aged, Animals, Child, Humans, Middle Aged, Sensitivity and Specificity.
Abstract
Serological assays based on the detection of immunoglobulin (Ig) G4 antibodies to crude filarial extracts are widely used for epidemiological and diagnostic purposes. We tested 195 samples collected in 1998 from an area of Brazil where filariasis is not endemic and 13 (6.7%) had levels of antifilarial IgG4 antibodies that were defined as positive. Both Strongyloides infection and the presence of Strongyloides antibody responses were associated with higher antifilarial antibody responses. None of the specimens had a positive response to the Brugia malayi recombinant antigen (Bm14). These data suggest that serodiagnostic assays based on the use of crude filarial antigens should be interpreted with caution because of the potential for cross-reactivity with Strongyloides.
PubMed: 12886811
Affiliations:
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Le document en format XML
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xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Child</term><term>Humans</term><term>Middle Aged</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Humains</term><term>Sensibilité et spécificité</term><term>Sujet âgé</term><term>Test ELISA</term><term>Tests sérologiques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Brésil</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Serological assays based on the detection of immunoglobulin (Ig) G4 antibodies to crude filarial extracts are widely used for epidemiological and diagnostic purposes. We tested 195 samples collected in 1998 from an area of Brazil where filariasis is not endemic and 13 (6.7%) had levels of antifilarial IgG4 antibodies that were defined as positive. Both Strongyloides infection and the presence of Strongyloides antibody responses were associated with higher antifilarial antibody responses. None of the specimens had a positive response to the Brugia malayi recombinant antigen (Bm14). These data suggest that serodiagnostic assays based on the use of crude filarial antigens should be interpreted with caution because of the potential for cross-reactivity with Strongyloides.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><noCountry><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name><name sortKey="Pires, M L" sort="Pires, M L" uniqKey="Pires M" first="M L" last="Pires">M L Pires</name></noCountry><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Muck, A E" sort="Muck, A E" uniqKey="Muck A" first="A E" last="Muck">A E Muck</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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